High-Resolution Zero-Field NMR <i>J</i>‑Spectroscopy
of Aromatic Compounds
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Abstract
We report the acquisition and interpretation
of nuclear magnetic
resonance (NMR) <i>J</i>-spectra at zero magnetic field
for a series of benzene derivatives, demonstrating the analytical
capabilities of zero-field NMR. The zeroth-order spectral patterns
do not overlap, which allows for straightforward determination of
the spin interactions of substituent functional groups. Higher-order
effects cause additional line splittings, revealing additional molecular
information. We demonstrate resonance linewidths as narrow as 11 mHz,
permitting resolution of minute frequency differences and precise
determination of long-range <i>J</i>-couplings. The measurement
of <i>J</i>-couplings with the high precision offered by
zero-field NMR may allow further refinements in the determination
of molecular structure and conformation
