<p>(<b>A</b>) Population survival data and Dornhorst model best fits for <i>Bcl-x<sup>+/Plt20</sup></i> (blue), wild-type (green) and <i>Bak<sup>−/−</sup></i> (red) mice. A Monte Carlo technique was used to generate estimates of confidence intervals for the model parameters – (<b>B</b>) natural life span, <i>T</i>, (<b>C</b>) standard deviation of natural life span (always 0 hr for this model), (<b>D</b>) random loss rate constant, <i>r</i>, and (<b>E</b>) random loss fraction, <i>f</i>. 1000 Monte Carlo simulations were performed and fit to obtain parameters – box-and-whisker plots indicate median, interquartile range, 2.5 and 97.5 percentiles, and outliers are plotted as individual dots.</p
