<i>H. pylori</i>, ZEB1, p65 NF-κB, E-cadherin immunostaining and miR-200b <i>in situ</i> hybridization in non infected human gastric mucosa (left pannels) or mucosa infected with <i>cag</i>PAI+ <i>H. pylori</i> (right pannels).
<p>Images are representatives of the detection by immunohistochemistry coupled to peroxydase activity (in brown) of <i>H. pylori</i> in the lumen of gastric glands at the apical surface of gastric epithelial cells, which display an intense ZEB1 and p65 expression mainly in the nucleus, despite a similar E-cadherin expression and localization at cell/cell junction in the <i>H. pylori</i> infected specimen and the non-infected one. MiR-200b detected by ISH coupled to phosphatase alkaline activity (in dark blue) is highly expressed in gastric glands of <i>H. pylori</i>–infected case. Typical images of the same case out of three infected patients and the same case out of three uninfected cases are shown. Bar, 50 µm.</p
