Iron-Catalyzed Cycloaddition
Reaction of Diynes and Cyanamides at Room Temperature
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Abstract
An iron-catalyzed [2 + 2 + 2] cycloaddition reaction
of diynes and cyanamides at room temperature is reported. Highly substituted
2-aminopyridines were obtained in good to excellent yields with high
regioselectivity. Insights toward the reaction process were investigated
through in situ IR spectra and control experiments. In this iron-catalyzed
cycloaddition reaction, the active iron species was generated only
in the presence of both alkynes and nitriles. The lower reaction temperature,
broad substrates scope, and inversed regioselectivity make it a complementary
method to the previously developed iron catalytic system