Comparison of Logan-<i>V</i><sub>T</sub> results in cortical and subcortical regions for healthy volunteers, alcoholic subjects and cannabis smokers, obtained with full input and the PBIF.
<p>Results at baseline in alcoholic subjects (A) and cannabis smokers (B), compared to healthy controls for both full input and PBIF. PBIF provided accurate Logan-<i>V</i><sub>T</sub> values in healthy subjects and alcoholic patients and closely replicated previous findings of widespread downregulation. In cannabis smokers, PBIF underestimated Logan-<i>V</i><sub>T</sub> (arrows); the results suggest the erroneous conclusion that downregulation also occurred in subcortical regions.</p
