2,2′-Biphenols via Protecting Group-Free Thermal
or Microwave-Accelerated Suzuki–Miyaura Coupling in Water
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Abstract
User-friendly protocols
for the protecting group-free synthesis
of 2,2′-biphenols via Suzuki–Miyaura coupling of <i>o</i>-halophenols and <i>o</i>-boronophenol are presented.
The reactions proceed in water in the presence of simple additives
such as K<sub>2</sub>CO<sub>3</sub>, KOH, KF, or TBAF and with commercially
available Pd/C as precatalyst. Expensive or laboriously synthesized
ligands or other additives are not required. In the case of bromophenols,
efficient rate acceleration and short reaction times were accomplished
by microwave irradiation
