Pd-Catalyzed Asymmetric Allylic Etherification Using
Chiral Biphenol-Based Diphosphinite Ligands and Its Application for
The Formal Total Synthesis of (−)-Galanthamine
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Abstract
A library
of novel chiral biphenol-based diphosphinite (BOP) ligands
was designed and created. These BOP ligands were applied to a Pd-catalyzed
intermolecular allylic etherification reaction, which provided a key
intermediate for the formal total synthesis of (−)-galanthamine
with 97% ee in 97% yield