<p><b>A</b>) Presence of 254 nutrient utilization pathways in genomes of 153 mammalian pathogens (excluding all <i>Salmonella</i> serovars). Data were based on pathway annotations available in MetaCyc <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003301#ppat.1003301-Caspi1" target="_blank">[62]</a>. Degradation pathways for nutrients that support <i>Salmonella</i> in mouse spleen were highly overrepresented among pathogen genomes (<i>P</i><0.001; Mann-Whitney U test) suggesting similar nutritional preferences (filled circles; 1, purine nucleosides; 2, pyrimidine nucleosides; 3, fatty acids; 4, glycerol; 5, arginine; 6, N-Acetylglucosamine; 7, glucose; 8, gluconate). <b>B</b>) Depletion frequency of 118 biosynthesis pathways in mammalian pathogens. The values represent differences in pathway frequency in sets of 153 pathogens and 316 environmental bacteria (see text for explanation). Biosynthesis pathways for biomass components that <i>Salmonella</i> could obtain from the host were selectively depleted among pathogen genomes (<i>P</i><0.0001; Mann-Whitney U test) suggesting similar host supplementation patterns (filled circles; 1, tyrosine; 2, histidine; 3, arginine; 4, cysteine; 5, methionine; 6, tryptophan; 7, threonine; 8, valine; 9 leucine; 10, isoleucine; 11, proline; 12, pyridoxal; 13, purine nucleosides; 14, pyrimidine nucleosides; 15, glutamine; 16, thiamin; 17, pantothenate).</p
