Isolation of Ciliatamide D from a Marine Sponge <i>Stelletta</i> sp. and a Reinvestigation of the Configuration
of Ciliatamide A
- Publication date
- Publisher
Abstract
A new lipopeptide, ciliatamide D
(<b>1</b>), was isolated from a marine sponge <i>Stelletta</i> sp., collected at Oshimashinsone, together with the known compound
ciliatamide A (<b>2</b>). Ciliatamide D (<b>1</b>) is
a congener of <b>2</b>, in which <i>N</i>-Me-Phe is
replaced by <i>N</i>-Me-Met(O). Marfey’s analysis
of the acid hydrolysate of <b>1</b> demonstrated that the two
constituent amino acids were both in the l-form. This result
prompted us to carefully investigate the configuration of <b>2</b>, resulting in the assignment of the l-form for both residues