Paper-Based
SlipPAD for High-Throughput Chemical Sensing
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Abstract
We report a paper analytical device
(PAD) that is based on the
SlipChip concept. This SlipPAD enables robust, high-throughput, multiplexed
sensing while maintaining the extreme simplicity of paper-based analysis.
The SlipPAD is comprised of two wax-patterned paper fluidic layers.
By slipping one layer relative to the other, solutions wick simultaneously
into a large array of sensing reservoirs or sequentially into a large
array of channels to carry out homogeneous or heterogeneous assays,
respectively. The applicability of the device to high-throughput multiplex
chemical analysis is demonstrated by colorimetric and fluorescent
assays