Building a Sulfonamide Library by Eco-Friendly Flow
Synthesis
- Publication date
- Publisher
Abstract
A rapid and eco-friendly synthesis
of a sulfonamide library under
flow conditions is described. The study illustrates an efficient,
safe, and easily scalable preparation of sulfonamides by use of a
meso-reactor apparatus, thus demonstrating the impact of flow technologies
within drug discovery. Waste minimization, employment of green media,
and nontoxic reactants are achieved by the optimization of the flow
setup and experimental protocol designed to sequentially synthesize
primary, secondary, and tertiary sulfonamides. Isolation of the products
involves only extraction and precipitation affording pure compounds
in good to high yields without further purification for biological
evaluation