Enantioselective Synthesis of α‑Tri-
and α‑Tetrasubstituted Allylsilanes by Copper-Catalyzed
Asymmetric Allylic Substitution of Allyl Phosphates with Silylboronates
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Abstract
A copper/<i>N</i>-heterocyclic carbene-catalyzed asymmetric
allylic substitution of allyl phosphates with a silylboronate has
been developed to give highly enantioenriched allylsilanes. High regioselectivity
has been achieved by employing NaOH as the base, and this catalyst
system is effective for both γ-mono- and disubstituted allyl
phosphates