Primary Amines as Directing Groups in the Ru-Catalyzed
Synthesis of Isoquinolines, Benzoisoquinolines, and Thienopyridines
- Publication date
- Publisher
Abstract
Isoquinolines, benzoisoquinolines,
thieno[3,2-<i>c</i>]pyridines and fused heteroaryl[2,3-<i>c</i>] pyridines,
with a wide variety of substituents at different positions of the
aromatic or heteroaromatic rings, have been synthesized by Ru-catalyzed
oxidative coupling of a broad range of benzylamines or heterocycles
with internal alkynes. All benzylamines and heterocycles have unprotected
primary amines as efficient directing groups