A Sonogashira Cross-Coupling/5-<i>exo</i>-dig Cyclization/Ionic Hydrogenation Sequence: Synthesis of 4‑Substituted 3‑Azabicyclo[3.1.0]hexan-2-ones from 2‑Iodo­cyclo­propane­carboxamides

Abstract

A variety of 4-substituted 3-azabicyclo[3.1.0]­hexan-2-ones have been prepared from 2-iodocyclopropanecarboxamides by a three-step sequence involving a copper-free Sonogashira coupling with terminal aryl- or heteroarylalkynes, followed by a 5-<i>exo</i>-dig cyclization and an ionic hydrogenation