Synthesis of Stereochemically and Skeletally Diverse
Fused Ring Systems from Functionalized <i>C</i>‑Glycosides
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Abstract
A diversity-oriented synthesis (DOS)
strategy was developed for
the synthesis of stereochemically diverse fused-ring systems containing
a pyran moiety. Each scaffold contains an amine and methyl ester for
further diversification via amine capping and amide coupling. Scaffold
diversity was evaluated in comparison to previously prepared scaffolds
by a shape-based principal moments of inertia (PMI) analysis