Influence of Surface Chemistry on Particle Internalization
into Giant Unilamellar Vesicles
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Abstract
Cellular uptake of materials plays
a key role in their biomedical
applications. In this work, based on the cell-mimic giant unilamellar
vesicles (GUVs) and a novel type of microscale materials consisting
of stimuli-responsive poly(<i>N</i>-isopropylacrylamide)
microgel particles and the incorporated lipids, the influence of particle
surface chemistry, including hydrophobic/hydrophilic property and
lipid decorations, on the adsorption and consequent internalization
of particles into GUVs was investigated. It is found that the decoration
of particle surface with lipids facilitates the adsorption of particles
on GUV membrane. After that, the hydrophobic property of particle
surface further triggers the internalization of particles into GUVs.
These results demonstrate the importance of surface properties of
particles on their interactions with lipid membranes and are helpful
to the understanding of cellular uptake mechanism