<p><b>A,</b> 5421 CNVs were detected in 1752 druggable genes across the sample. The 20<sup>th</sup> (0.7×) and 80<sup>th</sup> (1.5×) percentiles served as cutoffs. <b>B,</b> Gains only (>1.5×). <b>C,</b> Losses only (<0.7×). <b>D,</b> Displaying PTEN family CNV values. <i>TPTE2</i> is the most frequently altered. Cutoffs are relaxed to <0.85× and >1.15× for display purposes.</p