Dabrafenib structure and activity against RAF kinases.

Alastair J. King (430098); Angela Hughes-Earle (430106); David E. Uehling (430111); Hongwei Qi (430109); Jingsong Yang (430102); Joseph A. Erhardt (430105); Katherine G. Moss (430101); Kelly E. Fedorowicz (430103); Kimberly N. Smitheman (430104); Laurie S. Kane-Carson (430107); Marc R. Arnone (430099); Maureen R. Bleam (430100); Robert H. Sinnamon (430108); Sylvie G. Laquerre (430112); Tara R. Rheault (430110)

Dabrafenib structure and activity against RAF kinases.

Authors: Alastair J. King (430098)
Angela Hughes-Earle (430106)
David E. Uehling (430111)
Hongwei Qi (430109)
Jingsong Yang (430102)
Joseph A. Erhardt (430105)
Katherine G. Moss (430101)
Kelly E. Fedorowicz (430103)
Kimberly N. Smitheman (430104)
Laurie S. Kane-Carson (430107)
Marc R. Arnone (430099)
Maureen R. Bleam (430100)
Robert H. Sinnamon (430108)
Sylvie G. Laquerre (430112)
Tara R. Rheault (430110)
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Doi

Abstract

<p>Dabrafenib chemical structure (A). Dabrafenib potency (IC<sub>50</sub>) was measured against the kinase activity of various BRAF orthologs, human BRAF mutants, and human CRAF (B).</p

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Last time updated on 12/02/2018