Emilio Castro (1827970)

F. Javier Arias (1397713)

J. Carlos Rodríguez-Cabello (1397716)

João F. Mano (1431895)

Rui R. Costa (1487530)

Inspired by the cells’ structure,
we present compartmentalized
capsules with temperature and magnetic-based responsiveness and hierarchical
organization ranging from the nano- to the visible scales. Liquefied
alginate macroscopic beads coated with a layer-by-layer (LbL) chitosan/alginate
shell served as containers both for model fluorophores and microcapsules,
which in their turn encapsulated either another fluorophore or magnetic
nanoparticles (MNPs). The microcapsules were coated with a temperature-responsive
chitosan/elastin-like recombinamer (ELR) nanostructured shell. By
varying the temperature from 25 to 37 °C, the two-hour release
of rhodamine encapsulated within the microcapsules and its diffusion
through the external compartment decreased from 84% and 71%. The devices
could withstand handling and centrifugal stress, with 50% remaining
intact at a rotation speed of 2000<i>g</i>. MNPs attributed
magnetic responsiveness toward external magnetic fields. Such a customizable
system can be envisaged to transport bioactive agents and cells in
tissue engineering applications

FigShare

Multifunctional Compartmentalized Capsules with a
Hierarchical Organization from the Nano to the Macro Scales

Delattre, Miguel

Ocler, Rodolph

Moulette, Pascal

Rimeyko, Karine

HAL-Lyon 3

Singularity of qualitative research: from collecting information to producing results

https://figshare.com/articles/Multifunctional_Compartmentalized_Capsules_with_a_Hierarchical_Organization_from_the_Nano_to_the_Macro_Scales/2398108