Highly <i>Z</i>‑Selective and Enantioselective Ring-Opening/Cross-Metathesis Catalyzed by a Resolved Stereogenic-at-Ru Complex

Abstract

The synthesis of a ruthenium complex that catalyzes <i>Z</i>-selective (up to 98% <i>Z</i>) asymmetric ring-opening/cross-metathesis with high enantioselectivity (up to 95% ee) is reported. The synthesis of the catalyst features the resolution of a chelating N-heterocyclic carbene complex by ligand substitution with a chiral carboxylate