Domino Elimination/Nucleophilic Addition in the Synthesis
of Chiral Pyrrolidines
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Abstract
Polyhydroxylated
pyrrolidines have been synthesized in a one-pot
procedure by the addition of an organometallic reagent to isoxazolidines
obtained by a 1,3-dipolar cycloaddition between nitrones and vinylsulfones.
This method highlights sulfone reactivity and provides an easy approach
for the preparation of chiral pyrrolidines using cyclic imines as
key intermediates