Enantioselective Synthesis of Pladienolide B and Truncated Analogues as New Anticancer Agents

Abstract

An enantioselective synthesis of natural anticancer macrolide pladienolide B is described. The synthetic highlights include Sharpless asymmetric epoxidation, ring closing metathesis (RCM), Ireland–Claisen rearrangement, Shi epoxidation, and Pd-catalyzed Stille coupling as key steps. The synthetic route also allowed the synthesis of the truncated analogues (<b>41a</b>–<b>d</b>) of pladienolide B