Rhodium-Catalyzed C3-Selective Alkenylation of Substituted
Thiophene-2-carboxylic Acids and Related Compounds
- Publication date
- Publisher
Abstract
The
regioselective C3-alkenylation of thiophene-2-carboxylic acids
can be achieved effectively via rhodium/silver-catalyzed oxidative
coupling with alkenes, unaccompanied by decarboxylation. A wide range
of substrates including brominated thiophenecarboxylic acids and furan-2-carboxylic
acids can be employed together with styrenes as well as acrylates.
The present catalyst system is also applicable to ortho-alkenylation
of benzoic acids
