Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge <i>Hippospongia lachne</i>

Abstract

Hippolachnin A (<b>1</b>), a polyketide possessing an unprecedented carbon skeleton with a four-membered ring, was isolated from the South China Sea sponge <i>Hippospongia lachne</i>. The structure was elucidated using MS and NMR spectroscopic analyses, and the absolute configuration was determined using a calculated ECD method. Hippolachnin A demonstrated potent antifungal activity against three pathogenic fungi, <i>Cryptococcus neoformans</i>, <i>Trichophyton rubrum</i>, and <i>Microsporum gypseum</i>, with a MIC value of 0.41 μM for each fungus