<p>The V1V2 region of SF162 is illustrated as (A) a schematic diagram, and as (B) a 3D model where the effect of amino acid substitutions on binding is indicated and coded by color: Red: residues where binding of at least six conformational V2 mAbs was reduced to ≤15% of binding to wildtype; Orange: binding of at least six conformational V2 mAbs where binding was reduced to ≤50% of wildtype; Dark grey: effect dependent on amino acid substitution. Dashed lines outline the surface area of the LDV integrin binding site.</p
