A Highly Chemoselective, Zr-Catalyzed C–O Bond
Functionalization of Benzofuran
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Abstract
The chemoselective C–O bond
functionalization of benzofuran
with an aluminum dihydride may be catalyzed by zirconocene dichlorides.
The reaction proceeds with the formal addition of a C–O bond
to, and elimination of dihydrogen
from, aluminum. The product of C–O bond alumination reacts
with benzaldehyde via insertion of the carbonyl into the newly formed
Al–C bond