One-Pot Asymmetric Synthesis of Seven-Membered Carbocycles Cyclohepta[<i>b</i>]indoles via a Sequential Organocatalytic Michael/Double Friedel–Crafts Alkylation Reaction

Abstract

A new method has been developed for the enantioselective synthesis of highly functionalized cyclohepta[<i>b</i>]indoles with high enantioselectivity (up to 96% <i>ee</i>). The process combines an enantioselective organocatalytic Michael addition and a highly efficient double Friedel–Crafts reaction sequence in one pot with good yields and stereoselectivity. The structures and absolute configurations of the products were confirmed by X-ray analysis