A Ratiometric Near-Infrared Fluorescent Probe for Hydrazine and Its <i>in Vivo</i> Applications
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Abstract
Based on modulation of the conjugated polymethine π-electron system of a cyanine dye derivative, a ratiometric near-infared fluorescent probe (Cy7A) for hydrazine (N<sub>2</sub>H<sub>4</sub>) has been designed and synthesized. Cy7A can be selectively hydrazinolysized with great changes in its fluorescent excitation/emission profiles, which makes it possible to detect N<sub>2</sub>H<sub>4</sub> in water samples and living cells and, for the first time, visualize N<sub>2</sub>H<sub>4</sub> in living mice
