Ligations from Tyrosine Isopeptides via 12- to 19-Membered
Cyclic Transition States
- Publication date
- Publisher
Abstract
Efficient syntheses of <i>O</i>-acyl Tyr-peptides allow
chemical long-range ligation (<i>O</i>-acyl to <i>N</i>-acyl transfer) via each of 12- to 19-membered cyclic transition
states. The results represent the first examples of successful isopeptide
ligations starting from <i>O</i>-acyl Tyr-peptides