Ligations from Tyrosine Isopeptides via 12- to 19-Membered Cyclic Transition States

Abstract

Efficient syntheses of <i>O</i>-acyl Tyr-peptides allow chemical long-range ligation (<i>O</i>-acyl to <i>N</i>-acyl transfer) via each of 12- to 19-membered cyclic transition states. The results represent the first examples of successful isopeptide ligations starting from <i>O</i>-acyl Tyr-peptides