<p>The goals of the Simons Simplex Collection (SSC) are to acquire the largest sample to date of simplex families with idiopathic autism in a highly compressed time-frame, maintain the highest data quality standards and disseminate data and biospecimens to the research community efficiently. Long-term requirements include support for additional studies and integration with partner systems such as the National Database for Autism Research (NDAR) and the Interactive Autism Network (IAN). The Simons Foundation partnered with a software vendor (Prometheus Research, LLC) to develop a distributed, Web-based, information system called SFARI Base.</p