<p>Effect of (<b>A</b>) random allocation to treatment groups, (<b>B</b>) blinded induction of ischaemia and, (<b>C</b>) blinded assessment of outcome on improvement in neurobiological score. The shaded gray bar represents the 95% confidence limits of the global estimate. The vertical error bars represent the 95% confidence intervals for the individual estimates. The width of each bar reflects the log of the number of animals contributing to that comparison.</p