Histological analysis of <i>Ric8a</i><sup><i>CKO</i></sup> mutants brains and comparison to littermate control mice.

Abstract

<p>(<b>A</b>–<b>D</b>) Representative images of hematoxylin-eosin stained P3 coronal brain sections. No gross difference was detected in <i>Ric8a</i><sup><i>CKO</i></sup> brain. (<b>A</b> and <b>B</b>) Anterior sections of neonatal brains. (<b>a</b> and <b>b</b>) Magnified image of neocortex layers from black boxes in A and B respectively. (<b>C</b> and <b>D</b>) Posterior part of neonatal brains. (<b>c</b> and <b>d</b>) Magnified image of cerebellar cortex layers from white boxes in C and D respectively. (<b>E</b> and <b>F</b>) Representative spinal cord sections from thoracic region. Motor neurons are indicated with black arrowheads. (<b>e</b> and <b>f</b>) Magnified image of ventral horns from E and F respectively. Abbreviations: cc, <i>corpus callosum</i>; Ce, cerebellum; cp, <i>caudate putamen</i>; dg, dentate gyrus; EGL, external granular layer; GL, granular layer; Pc, Purkinje cell; PCL, Purkinje cell layer; I, II/III, IV/V, VI, neocortical cell layers. Scale bars: (A-D) 1 mm; (E and F) 200 µm; (a-f) 100 µm.</p

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