<p>PbAus-infected C57Bl/6 mice (n = 10 per group, non-treated; n = 6 per group, nSSL-BMS) were administered 5% dextrose or 20 mg/kg nSSL-BMS (arrows) every other day, starting on day 5p.i., followed by 2×10 mg/kg/d artemisone after the cerebral phase, on days 11–15 p.i. (double arrows). No effect on the development of parasitemia was observed following administration of 5% dextrose. Administration of nSSL-BMS significantly reduced clinical score when started on day 5 p.i. or day 6 p.i. (p<0.001, p<0.05 vs. no treatment, respectively) and increased survival (p<0.01 and p<0.001 vs. non-treated), creating a time-window for antiplasmodial treatment and cure. *Day 15 p.i. nSSL-BMS: n = 6 (days 5,7,9 p.i. and days 6,8 p.i.).</p
