<i>C. difficile</i> spores accumulate in the cecum, colon, and feces of CamSA-treated animals.

Abstract

<p>(A) Amount of <i>C. difficile</i> spores recovered at different time points following spore challenge from the cecum (white bars) and colon (black bars) of mice treated with 50 mg/kg CamSA. Student’s unpaired <i>t</i>-test was used to determine the significance of difference of means. *indicates recovered spores significantly below 72 hour levels (<i>P</i> = 0.019; Student's <i>t</i>-test). **indicates recovered spores significantly below 72 hour levels (<i>P</i> = 0.049; Student's <i>t</i>-test). (B) Feces were collected from cages housing five mice challenged with <i>C. difficile</i> spores and treated with 50 mg/kg CamSA. Closed bars represent <i>C. difficile</i> spores. The amount of <i>C. difficile</i> vegetative cells in CamSA-treated animals was negligible (<10% compared to spore counts). Standard deviations represent at least five independent measures. Recovered CFU and recovered spores represent mean values from a pool of five animals.</p

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