<p><b>A.</b> Systolic blood pressure is stable in WT from 2 mo to 1 yr, but significantly increases from 1 yr to 2 yr (p<0.001, ANOVA). D3KO show similar values to 2 yr old WT. <b>B.</b> Diastolic blood pressure increases gradually with age in WT and reaches its peak at 2 years of age. D3KO show levels comparable to those of the 2 yr old WT and significantly higher than 2 mo or 1 yr old WT (p<0.001, ANOVA). <b>C.</b> Mean arterial pressure (MAP) increases gradually with age in WT and reaches its peak at 2 years of age. D3KO show levels comparable to those of the 2 yr old WT and significantly higher than 2 mo or 1 yr old WT (p<0.001, ANOVA). <b>D.</b> Heart rate reaches a peak in 1 yr old WT and drops significantly in the 2 yr old WT, and values are similar between 2 yr old WT and 2 mo old D3KO. <b>E.</b> The rate-pressure product increases with age in WT and is similar between 2 yr old WT and 2 mo old D3KO.</p
