<p>(A) Diagram of NF-kB promoters on <i>FANCD2</i> and <i>BRCA1</i> genes. (B) Expression by qPCR of <i>FANCD2</i> following proteasome inhibition ±30 nM (A549) or 50 nM (NCI-H460) bortezomib or ± inducible <i>PSMA1</i> shRNA, and ±10 Gy IR. All values are normalized to ACTB and all results are mean ± SEM. (C) As in (B) but with BRCA1. (D) NSCLC cell survival following bortezomib and IR is partially rescued by <i>IkBα</i> siRNA knockdown when performed in advance. Cell viability was assayed using an ATP luminescence-based assay measuring relative luminescent units (RLU). All results are mean ± SEM.</p
