Total Synthesis of (+)-18-<i>epi-</i>Latrunculol A

Abstract

An enantioselective total synthesis of the cytotoxic latrunculin congener (+)-18-<i>epi</i>-latrunculol A has been achieved. Key steps in the synthetic route include an acid-mediated enone cyclization/equilibration sequence, a Carreira alkynylation, and a late-stage Mitsunobu macrolactonization to construct the macrolide skeleton