Magnetic, Acidic, Ionic Liquid-Catalyzed One-Pot Synthesis
of Spirooxindoles
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Abstract
Magnetic, supported, acidic ionic
liquid was synthesized and identified
as an efficient catalyst for the one-pot synthesis of novel spirooxindole
derivatives at mild conditions and in good yields. Three component
reaction of wide variety of substituted isatins, 1,3-dimethyl-2-amino
uracil, and barbituric acid, thiobarbituric acid, and dimedon as 1,3-dicarbonyl
compounds gives the target compounds. Operational simplicity, low
cost, high yields, environmental friendliness, wide applicability
and reusability and easy recovery of the catalyst using an external
magnet are the key features of this methodology