<p>(<b>A</b>) Points indicate treatment groups which were originally represented by a vector containing the fold-changes of all signature genes and then transformed to its two principal components. Here, the informative genes for discriminating GC vs. NGC after 3 days of repeated dosing were used. Groups of male animals are drawn as squares and female ones as circles. The fill color of the points indicates the compound class. Polygons indicate the convex hulls of clusters corresponding to either male or female mice treated with a certain class of compounds. (<b>B</b>) Similar plot as in (A), but the multi-gene signature for GC vs. NGC classification after 14 days was used here. (<b>C</b>) The heatmap provides a graphical representation of the fold-changes of 15 selected signature genes from the 14-day signature for GC vs. NGC classification. Rows correspond to genes and columns to treatment groups. Upregulated genes are colored in red and downregulated ones in green. The colorbar on top indicates the corresponding compound classes. (<b>D</b>) Heatmaps showing confidence of predictions made by diverse C vs. NC classifiers for male (M) and female (F) mice treated with CPA, TAA and WY for 3 days (left heatmap) or 14 days (right heatmap). (<b>E</b>) Similar illustration as in (D) showing prediction outcomes of GC vs. NGC classifiers.</p
