Co-expression network of Bp condition-dependent transcription.

Abstract

<p>(A) Co-expression network. Nodes are individual genes, connected to one another by significant co-expression relationships (mutual information score ). The colours represent clusters over-represented in different Riley annotations, and their respective annotations are provided at the bottom. (B) Condition dependent cluster expression. The heat-map depicts representative clusters and patterns of expression across conditions. Gene expression levels were mean-normalized. (C) Inter-cluster relationships. The MRCN unit M036 consists of two clusters: C131 and C265, which include genes encoding proteins for degrading misfolded proteins and other genes with hypothetical functions. Thickness of edges represents the strength of the co-expression relationship between two genes. (D) Condition groups. The different condition-specific transcriptional profiles were clustered to one another based on similarities in expression of genes from the Bp core genome. Condition groups deemed to be stable by bootstrap assessment are marked in colors.</p