“Toll-like receptor signaling pathway” of zebrafish genes after SVCV infection.

Abstract

<p>The gene boxes containing the zebrafish gene short names in <i>italics</i> and their relationships were obtained from the corresponding human KEGG-pathway. All those genes appearing in the Figure were assayed for transcript expression. Capital letters, inputs (black) and outputs (blue) of the pathway. Vertical parallel lines, cellular membranes. Continuous black arrows, activation between gene products. Discontinuous black arrows, inhibition between gene products. Gray form, main pathway. Folds were calculated as described in methods by the formula, fluorescence value 2- or 30-days after infection / fluorescence mean value in non-infected controls. Red <i>italic</i> letters, downregulated transcripts with folds <0.5. Orange <i>italic</i> letters, downregulated transcripts with folds <0.66. Bright green <i>italic</i> letters, upregulated transcripts with folds >2. Dark green <i>italic</i> letters, upregulated transcripts with folds >1.5. Black <i>italic</i> letters, not differentially expressed. Gene short names surrounded by an square, multipath genes. Gray form, downstream pathway beginning with cell membrane toll-like receptors (tlr1, tlr2, tlr4, tlr5b and tlr6). Ovoid brown forms, <i>tlrs</i>. Gene <i>italic</i> letters were colored as follows: red <0.5, orange <0.66, dark green >1.5 and bright green >2 folds. <b>A</b>, 2-days after SVCV infection. <b>B</b>, 30-days after SVCV infection (survivors).</p

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