Cynthia G. Whitney (203666)

Daniel R. Feikin (153640)

Eunice W. Kagucia (462405)

Jennifer D. Loo (462406)

Katherine L. O’Brien (462225)

Matthew R. Moore (462409)

Milo A. Puhan (282240)

Orin S. Levine (240485)

Ruth Link-Gelles (462407)

Thomas Cherian (462408)

<p>Site abbreviations: ABCs (USA Active Bacterial Core Surveillance); AIP (USA Alaska); Site abbreviations: ABCs, USA Active Bacterial Core Surveillance; AIP, USA Alaska; AUSI, Australian Indigenous Northern Territory; AUSN, Australian Non-Indigenous; CAL, Canada Calgary; CHE, Switzerland; CZE, Czech Republic; DEN, Denmark; E&W, England and Wales; GRC, Greece; ISR, Israel; NAV, USA Navajo; NCK, USA Kaiser Permanente Northern California; NLD, The Netherlands; NOR, Norway; NZL, New Zealand; SCT, Scotland; URY, Uruguay; UTA, USA Utah.</p

The Francis Crick Institute

Vaccine serotype invasive pneumococcal disease summary rate ratio forest plots by post-introduction year from random effects meta-analysis for children aged <5 years.

Arredondo, Meritxell

Universitat Autònoma de Barcelona. Facultat de Veterinària

Diposit Digital de Documents de la UAB

African Swine Fever: an UpdateMeritxell ArredondoAutonomous University of Barcelona. February 2017There is no treatment nor vaccine1. INTRODUCTION3. ASF VIRUS4. COURSE OF THE DISEASE5. DIAGNOSIS6.  PREVENTION AND CONTROL8. CONCLUSIONSClinical diagnosisLaboratory diagnosis• STAMPING OUT• Cleaning and disinfection• Destroying or sterilizing contaminated pork products2. TRANSMISSIONPeracuteformAcute formSub-acute formChronic formDIVA vaccines(Sub-units or GMO)High virulent  isolates↑ mortality ratesLow virulent  isolates↓ mortality rates• Virus isolation (HAD, PCR)• Serology (ELISA, LFA)7.  FUTURE PERSPECTIVESdsDNA virusFamily AsfarviridaeARBOVIRUSIcosahedral form22 genotypesTarget cells:MACROPHAGESDifferential diagnosis• Classical Swine FeverThe aim of this bibliographic review is to provide an update on the current situation of African SwineFever (ASF) worldwide, discussing its main epidemiological and pathogenic aspects. ASF is a highlycontagious hemorrhagic disease that affects both domestic and wild pigs. This OIE-notifiable disease isconsidered one of the most important transboundary illnesses in pigs. For many years ASF hasremained endemic in Sardinia and Southern Africa. However, only a few years ago it was re-introducedin Europe once again through the Caucasus.• Generalized hemorrhagesFig 1. Countries where ASF is present (red, rose, purple). Fig 2. ASFV main transmission routes: sylvatic cycle, domestic cycle, through contaminated pork products and fomites.Fig 3. ASFV morphology.Fig 4. Macrophages infected with ASFV.Fig 5. Acute petechiae in the kidney.Fig 6. Positive HAD “rosette” test.ASFV has an important social and economic impact in the swine industry. Its potential to rapidly spread and produce long-termpersistent infection threatens many ASF-free European and Asian countries. Up to now, stamping out policies are the only measureable to control this disease, but they are ethically and financially difficult to accept. For this reason, the future control andelimination of ASFV occurrence depends on the development of an effective and safe DIVA vaccine .