<p>A, WsTR-I superimposed on to DsTR-I and DsTR-II. The model was constructed on Swiss-model workspace taking DsTRI (1ae1.pdb) as a template. Comparative representation was performed by UCSF Chimera package. WsTR-I, DsTR-I and DsTR-II are depicted as gray, purple and blue, respectively. NADPH and tropinone are visible in cleft of active site; B, Tropinone binding pocket of WsTR-I. A model was prepared by alignment of WsTR-I, DsTR-I and DsTR-II following energy minimization in Swiss-PDBviewer. Tropinone binding site was visualized by Ligand Explorer. Amino acids close to tropinone are labeled; C, Three dimensional (3-D) models of WsTR-I, DsTR-I and DsTR-II were aligned and analyzed in Pymol. Residues are lebelled in green (WsTR-I), cyan (DsTR-I) and magenta (DsTR-II). Tropinone is shown in orange.</p
