Loss of host TNFR1 does not affect the activation status of tumor-infiltrating T cells.
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Abstract
<p>Pancreata and spleens from naïve and tumor-bearing mice one and two weeks after tumor cell inoculation were explanted and prepared as single cell suspensions. T cells were analyzed for the expression of activation-associated surface receptors by flow cytometry. Furthermore, the percentage of T<sub>regs</sub>, myeloid cells and tumor cells was determined by flow cytometry (w/o tumor: B6.WT n = 8, B6.TNFR1 KO n = 6; d+7: B6.WT n = 7, B6.TNFR1 KO n = 6; d+15: B6.WT n = 7, B6.TNFR1 KO n = 7). *p≤0.05, **p≤0.01. Combined data from four independent experiments.</p
