Solubility of Nifedipine in Ethanol + Water and Propylene Glycol + Water Mixtures at 293.2 to 313.2 K

Abstract

The solubility of nifedipine (NIF) in binary mixtures of ethanol (EtOH) + water and propylene glycol (PG) + water at 293.2, 298.2, 303.2, 308.2, and 313.2 K was measured. The Jouyban–Acree model and its combination with van’t Hoff equation was used to predict the solubility of NIF in the mixed solvents at different temperatures. The solubility of NIF in EtOH + water mixtures have a maximum at 0.90 mass fraction of EtOH, but the solubility of NIF in PG + water reaches to the maximum value in neat PG. Both mixtures (EtOH + water and PG + water) have a maximum solubility at 313.2 K. A mean relative deviation (MRD) for the fitted data to the Jouyban–Acree model of 8.1% and for combined method of 7.4% was obtained. The predicted MRDs for the solubility data using previously trained models were 38.8%, 43.0%, and 43.9%, and the MRD for predicted density value was 7.3%