Antimycobacterial
Labdane Diterpenes from <i>Leucas stelligera</i>
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Abstract
Phytochemical investigation of the
acetone extract of the aerial
parts of <i>Leucas stelligera</i> afforded four new compounds
(<b>1</b>–<b>4</b>) belonging to the labdane diterpene
series as well as two known flavones, velutin (<b>5</b>) and
chrysoeriol (<b>6</b>). Structure elucidation of the new compounds
was carried out using 1D and 2D NMR spectroscopic data and single-crystal
X-ray crystallography of compound <b>1</b>. Compounds <b>1</b>–<b>4</b> exhibited selective antimycobacterial
activity against <i>Mycobacterium tuberculosis</i> with
IC<sub>50</sub> values in the range 5.02–9.80 μg/mL