Hydroxyclerodanes
from <i>Salvia shannoni</i>
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Abstract
Six new hydroxyclerodanes (<b>1</b>–<b>6</b>), named sepulturins A–F, and
four known diterpenes were isolated
from the leaves of <i>Salvia shannoni</i>. The structures
of these compounds were established by extensive analysis of their
NMR and MS spectroscopic data. The relative configurations of compounds <b>1</b> and <b>2</b> were determined by NOESY experiments
and were confirmed by single-crystal X-ray diffraction studies. All
of the isolated diterpenes possess tertiary OH groups. The structure
of infuscatin (<b>7</b>), a clerodane previously isolated from <i>S</i>. <i>infuscata</i>, was revised. Cytotoxic, antiprotozoal,
and anti-inflammatory activities of these compounds were evaluated
