Gabapentin Coordination Networks: Mechanochemical
Synthesis and Behavior under Shelf Conditions
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Abstract
Active
pharmaceutical ingredients (API) coordination complexes and networks
present a promising pathway for developing new bioinspired materials.
In the present study, we report several coordination networks of gabapentin
with Y(III), Mn(II), and several lanthanides (LnCl<sub>3</sub>), Ln
= La<sup>3+</sup>, Ce<sup>3+</sup>, Nd<sup>3+</sup>, Er<sup>3+</sup> obtained by mechanosynthesis. To the best of our knowledge, these
are among the first coordination networks of pharmaceuticals involving
lanthanides. These novel compounds proved to be unstable under shelf
conditions, are thermally stable until water release at approximately
80 °C, and decompose above 200–250 °C. The coordination
networks obtained present different structural architectures based
on mono-, di-, tri-, and hexa-metallic centers (herein called monomers,
dimers, trimers, and hexamers), and also a one-dimensional polymeric
chain was obtained. Gabapentin chelation modes are the same in most
of the networks, adopting three typical geometries: the bidentate
coordination – chelation, mode I; the bridge coordination,
mode II, and the “bidentate-bridge” coordination, mode
III. NMR studies show that the compounds have different behavior in
solution, where a single coordination mode seems to be present