Copper(II)
Complexes with 4‑Carbomethoxypyrrolidone
Functionalized PAMAM-Dendrimers: An EPR Study
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Abstract
The
internal flexibility and interacting ability of PAMAM-dendrimers
having 4-carbomethoxypyrrolidone-groups as surface groups (termed
Gn-Pyr), which may be useful for biomedical purposes, and ion traps
were investigated by analyzing the EPR spectra of their copper(II)
complexes. Increasing amounts (with respect to the Pyr groups) of
copper(II) gave rise to different signals constituting the EPR spectra
at room and low temperature corresponding to different coordinations
of Cu<sup>2+</sup> inside and outside the dendrimers. At low Cu<sup>2+</sup> concentrations, CuN<sub>4</sub> coordination involving the
DAB core is preferential for G3- and G5-Pyr, while G4-Pyr shows a
CuN<sub>3</sub>O coordination. CuN<sub>2</sub>O<sub>2</sub> coordination
into the external dendrimer layer was also contributing to G3- and
G4-Pyr spectra. The structures of the proposed copper–dendrimer
complexes were also shown. G4-Pyr displays unusual binding ability
toward Cu(II) ions. Mainly the remarkably low toxicity shown by G4-Pyr
and its peculiar binding ability leads to a potential use in biomedical
fields