<p>The panels show the percentage of T-cells releasing IFN-γ (A) and IL-2 (B) for CD4+ T-cells, and IFN-γ (C) and perforin (D) for CD8+ T-cells for each patient in control Group A (n = 10, circles), and vaccine Group B (n = 10, black dots). T-cell functions were analyzed after stimulation for 16 h with a pool of proteins representing the vaccine sequences. Lines represent median values. In panel (E) CD8+ cells releasing perforin at baseline week 0 and after 60 weeks in vaccine and control groups are shown. Differences within groups between baseline and week 60 levels in panel (E) are indicated for each individual, and the p-value calculated by Wilcoxon signed rank test.</p
